Version 5.4
Homo sapiens Protein: TMEM27
Summary
InnateDB Protein IDBP-46702.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM27
Protein Name transmembrane protein 27
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000369699
InnateDB Gene IDBG-46700 (TMEM27)
Protein Structure
UniProt Annotation
Function Regulator of SNARE complex function. Stimulator of beta cell replication. {ECO:0000269PubMed:16330323}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Kidney; collecting ducts. Pancreas; beta cells of islets. {ECO:0000269PubMed:11278314, ECO:0000269PubMed:16330323}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0035543 positive regulation of SNARE complex assembly
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0045956 positive regulation of calcium ion-dependent exocytosis
GO:0051957 positive regulation of amino acid transport
Cellular Component
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
GO:0031526 brush border membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HBJ8
PhosphoSite PhosphoSite-Q9HBJ8
TrEMBL
UniProt Splice Variant
Entrez Gene 57393
UniGene Hs.129614
RefSeq NP_065716
HUGO HGNC:29437
OMIM 300631
CCDS CCDS14170
HPRD 06668
IMGT
EMBL AF229179 AK313835 AY359060 BC014317 BC015099 BC050606 CH471074
GenPept AAG09466 AAH14317 AAH15099 AAH50606 AAQ89419 BAG36568 EAW98894

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca