Homo sapiens Gene: TMEM27
Summary
InnateDB Gene IDBG-46700.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM27
Gene Name transmembrane protein 27
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000147003
Encoded Proteins
transmembrane protein 27
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:15627318-15665031
Strand Reverse strand
Band p22.2
Transcripts
ENST00000380342 ENSP00000369699
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0035543 positive regulation of SNARE complex assembly
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0045956 positive regulation of calcium ion-dependent exocytosis
GO:0051957 positive regulation of amino acid transport
Cellular Component
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
GO:0031526 brush border membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.129614
RefSeq NM_020665
HUGO
OMIM
CCDS CCDS14170
HPRD 06668
IMGT
EMBL
GenPept
RNA Seq Atlas