InnateDB Protein
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IDBP-46821.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ZIC2
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Protein Name
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Zic family member 2
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Synonyms
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HPE5;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000365514
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InnateDB Gene
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IDBG-46819 (ZIC2)
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Protein Structure
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Function |
Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.
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Subcellular Localization |
Nucleus. Cytoplasm {ECO:0000250}. Note=Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus (By similarity). {ECO:0000250}.
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Disease Associations |
Holoprosencephaly 5 (HPE5) [MIM:609637]: A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. {ECO:0000269PubMed:11285244, ECO:0000269PubMed:15221788, ECO:0000269PubMed:19177455}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
O95409
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PhosphoSite |
PhosphoSite-O95409
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TrEMBL |
A0A024RDY6
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UniProt Splice Variant |
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Entrez Gene |
7546
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UniGene |
Hs.707293
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RefSeq |
NP_009060
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HUGO |
HGNC:12873
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OMIM |
603073
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CCDS |
CCDS9495
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HPRD |
04353
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IMGT |
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EMBL |
AF104902
AF193855
AL355338
CH471085
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GenPept |
AAC96325
AAG28409
CAH70367
EAX09030
EAX09031
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