InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CPM

Summary

InnateDB Protein

IDBP-46843.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CPM

Protein Name

carboxypeptidase M

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000339157

InnateDB Gene

IDBG-46841 (CPM)

Protein Structure

UniProt Annotation

Function

Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins. {ECO:0000269PubMed:12457462}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12457462}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:12457462}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004180	carboxypeptidase activity
GO:0004181	metallocarboxypeptidase activity
GO:0008270	zinc ion binding
GO:0016788	hydrolase activity, acting on ester bonds

Biological Process

GO:0006508	proteolysis
GO:0008152	metabolic process
GO:0009653	anatomical structure morphogenesis

Cellular Component

GO:0005886	plasma membrane
GO:0031225	anchored component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000834 Peptidase M14, carboxypeptidase A
IPR007036 Succinylglutamate desuccinylase/aspartoacylase
IPR008969 Carboxypeptidase-like, regulatory domain

PFAM

PF00246
PF04952

PRINTS

PR00765

PIRSF

PIRSF039012

SMART

SM00631

TIGRFAMs

Post-translational Modifications

Modification

Cross-References