Version 5.4
Homo sapiens Gene: CPM
Summary
InnateDB Gene IDBG-46841.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPM
Gene Name carboxypeptidase M
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135678
Encoded Proteins
IDBP-46843
carboxypeptidase M
IDBP-589381
carboxypeptidase M
IDBP-587237
carboxypeptidase M
IDBP-586213
carboxypeptidase M
IDBP-595094
carboxypeptidase M
IDBP-584814
carboxypeptidase M
IDBP-597807
carboxypeptidase M
IDBP-602383
carboxypeptidase M
IDBP-599974
carboxypeptidase M
IDBP-594459
carboxypeptidase M
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:68842197-68971570
Strand Reverse strand
Band q15
Transcripts
ENST00000338356 ENSP00000339157
ENST00000546556 ENSP00000447051
ENST00000551897 ENSP00000447455
ENST00000551568 ENSP00000448517
ENST00000546373 ENSP00000447255
ENST00000546912
ENST00000548954 ENSP00000446799
ENST00000551728 ENSP00000446573
ENST00000547134 ENSP00000450400
ENST00000547924
ENST00000548262 ENSP00000449911
ENST00000549781 ENSP00000448078
ENST00000549691
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
GO:0016788 hydrolase activity, acting on ester bonds
Biological Process
GO:0006508 proteolysis
GO:0008152 metabolic process
GO:0009653 anatomical structure morphogenesis
Cellular Component
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020183
View Gene Order
ENSBTAG00000013496
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654387 Hs.731804
RefSeq NM_001005502 NM_001874 NM_198320
HUGO
OMIM
CCDS CCDS8987
HPRD 00273
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca