InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TJP1

Summary

InnateDB Protein

IDBP-4686.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TJP1

Protein Name

tight junction protein 1 (zona occludens 1)

Synonyms

ZO-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000281537

InnateDB Gene

IDBG-4684 (TJP1)

Protein Structure

UniProt Annotation

Function

The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells. {ECO:0000269PubMed:21240187}.

Subcellular Localization

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Cell junction. Cell junction, gap junction. Note=Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact. Detected at the leading edge of migrating and wounded cells.

Disease Associations

Tissue Specificity

The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	106 [view]
Protein-Protein	100 [view]
Protein-DNA	5 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008022	protein C-terminus binding
GO:0019904	protein domain specific binding

Biological Process

GO:0001825	blastocyst formation
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0007043	cell-cell junction assembly
GO:0007605	sensory perception of sound
GO:0032496	response to lipopolysaccharide
GO:0035329	hippo signaling
GO:0042493	response to drug
GO:0043116	negative regulation of vascular permeability
GO:0045471	response to ethanol
GO:0061024	membrane organization
GO:0071000	response to magnetism
GO:0071333	cellular response to glucose stimulus
GO:1901350	cell-cell signaling involved in cell-cell junction organization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0005913	cell-cell adherens junction
GO:0005921	gap junction
GO:0005923	tight junction
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0016327	apicolateral plasma membrane
GO:0030054	cell junction
GO:0043296	apical junction complex
GO:0045177	apical part of cell
GO:0046581	intercellular canaliculus

Protein Structure and Domains

PDB ID

InterPro

IPR000906 ZU5 domain
IPR001452 SH3 domain
IPR001478 PDZ domain
IPR005417 Zona occludens protein
IPR005418 Zona occludens protein ZO-1
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR011511 Variant SH3 domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM