Version 5.4
Homo sapiens Protein: CPSF6
Summary
InnateDB Protein IDBP-46903.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPSF6
Protein Name cleavage and polyadenylation specific factor 6, 68kDa
Synonyms CFIM; CFIM68; HPBRII-4; HPBRII-7;
Species Homo sapiens
Ensembl Protein ENSP00000266679
InnateDB Gene IDBG-46901 (CPSF6)
Protein Structure
UniProt Annotation
Function Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping. {ECO:0000269PubMed:14690600, ECO:0000269PubMed:20695905, ECO:0000269PubMed:21295486, ECO:0000269PubMed:8626397, ECO:0000269PubMed:9659921}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15169763, ECO:0000269PubMed:20695905, ECO:0000269PubMed:9659921}. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 74 [view]
Protein-Protein 74 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006378 mRNA polyadenylation
GO:0006397 mRNA processing
GO:0051262 protein tetramerization
Cellular Component
GO:0005634 nucleus
GO:0005849 mRNA cleavage factor complex
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0042382 paraspeckles
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q16630
PhosphoSite PhosphoSite-Q16630
TrEMBL
UniProt Splice Variant
Entrez Gene 11052
UniGene Hs.702826
RefSeq NP_001287876
HUGO HGNC:13871
OMIM 604979
CCDS CCDS73494
HPRD
IMGT
EMBL AK223568 AK292024 BC000714 BC005000 CH471054 X67336 X67337
GenPept AAH00714 AAH05000 BAD97288 BAF84713 CAA47751 CAA47752 EAW97215

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca