Homo sapiens Gene: CPSF6
Summary
InnateDB Gene IDBG-46901.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPSF6
Gene Name cleavage and polyadenylation specific factor 6, 68kDa
Synonyms CFIM; CFIM68; HPBRII-4; HPBRII-7;
Species Homo sapiens
Ensembl Gene ENSG00000111605
Encoded Proteins
cleavage and polyadenylation specific factor 6, 68kDa
cleavage and polyadenylation specific factor 6, 68kDa
cleavage and polyadenylation specific factor 6, 68kDa
cleavage and polyadenylation specific factor 6, 68kDa
cleavage and polyadenylation specific factor 6, 68kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is one subunit of a cleavage factor required for 3\' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3\' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:69239537-69274358
Strand Forward strand
Band q15
Transcripts
ENST00000266679 ENSP00000266679
ENST00000435070 ENSP00000391774
ENST00000456847 ENSP00000391437
ENST00000550075 ENSP00000446670
ENST00000550987
ENST00000551516 ENSP00000450206
ENST00000547486
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 74 [view]
Protein-Protein 74 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006378 mRNA polyadenylation
GO:0006397 mRNA processing
GO:0051262 protein tetramerization
Cellular Component
GO:0005634 nucleus
GO:0005849 mRNA cleavage factor complex
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0042382 paraspeckles
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by FGFR in disease pathway
Signaling by FGFR mutants pathway
Signaling by FGFR1 mutants pathway
Signaling by FGFR1 fusion mutants pathway
Disease pathway
KEGG
mRNA surveillance pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.369606 Hs.611646 Hs.656303 Hs.702826
RefSeq NM_001300947 NM_007007 XM_005268589 XM_005268590
HUGO
OMIM
CCDS CCDS73494 CCDS8988
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas