Version 5.4
Homo sapiens Protein: AKR1E2
Summary
InnateDB Protein IDBP-47009.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKR1E2
Protein Name aldo-keto reductase family 1, member E2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000335034
InnateDB Gene IDBG-47005 (AKR1E2)
Protein Structure
UniProt Annotation
Function Catalyzes the NADPH-dependent reduction of 1,5-anhydro- D-fructose (AF) to 1,5-anhydro-D-glucitol. Can also catalyze the reduction of various aldehydes and quinones (By similarity). Has low NADPH-dependent reductase activity towards 9,10- phenanthrenequinone (in vitro). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity Testis-specific. {ECO:0000269PubMed:12604216}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0050571 1,5-anhydro-D-fructose reductase activity
Biological Process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR020471 Aldo/keto reductase subgroup
IPR023210 NADP-dependent oxidoreductase domain
PFAM PF00248
PRINTS PR00069
PIRSF PIRSF000097
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96JD6
PhosphoSite PhosphoSite-Q96JD6
TrEMBL
UniProt Splice Variant
Entrez Gene 83592
UniGene Hs.657944
RefSeq NP_001257950
HUGO HGNC:23437
OMIM
CCDS CCDS59209
HPRD 07472
IMGT
EMBL AB040820 AB040821 AB040822 AB055603 AC091817 AF263242 BC002862
GenPept AAH02862 AAK58523 BAC54565 BAC54566 BAC54567 BAC54568

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca