InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KDM3B

Summary

InnateDB Protein

IDBP-47084.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDM3B

Protein Name

lysine (K)-specific demethylase 3B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000326563

InnateDB Gene

IDBG-47082 (KDM3B)

Protein Structure

UniProt Annotation

Function

Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269PubMed:16603237}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver. {ECO:0000269PubMed:11087669, ECO:0000269PubMed:11687974}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016568	chromatin modification
GO:0055114	oxidation-reduction process