InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDIA4

Summary

InnateDB Protein

IDBP-47157.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDIA4

Protein Name

protein disulfide isomerase family A, member 4

Synonyms

ERp-72; ERP70; ERP72;

Species

Homo sapiens

Ensembl Protein

ENSP00000286091

InnateDB Gene

IDBG-47155 (PDIA4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	63 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0016853	isomerase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006457	protein folding
GO:0009306	protein secretion
GO:0034976	response to endoplasmic reticulum stress
GO:0045454	cell redox homeostasis
GO:0061077	chaperone-mediated protein folding

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0009986	cell surface
GO:0042470	melanosome

Protein Structure and Domains

PDB ID

InterPro

IPR001393 Calsequestrin
IPR005788 Disulphide isomerase
IPR005792 Protein disulphide isomerase
IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain
IPR017068 Protein disulphide-isomerase A4

PFAM

PF01216
PF13098
PF13192
PF13462
PF13905
PF00085

PRINTS

PR00312

PIRSF

PIRSF036862

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt