Version 5.4
Homo sapiens Protein: SPOP
Summary
InnateDB Protein IDBP-473386.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPOP
Protein Name speckle-type POZ protein
Synonyms BTBD32; TEF2;
Species Homo sapiens
Ensembl Protein ENSP00000420908
InnateDB Gene IDBG-57724 (SPOP)
Protein Structure
UniProt Annotation
Function Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. {ECO:0000269PubMed:14528312, ECO:0000269PubMed:15897469, ECO:0000269PubMed:16524876, ECO:0000269PubMed:19818708, ECO:0000269PubMed:22085717, ECO:0000269PubMed:22632832}.
Subcellular Localization Nucleus. Nucleus speckle.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:9414087}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 41 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
GO:0031463 Cul3-RING ubiquitin ligase complex
Protein Structure and Domains
PDB ID
InterPro IPR000210 BTB/POZ-like
IPR002083 MATH
IPR008974 TRAF-like
IPR011333 BTB/POZ fold
IPR013069 BTB/POZ
PFAM PF00917
PF00651
PRINTS
PIRSF
SMART SM00225
SM00061
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43791
PhosphoSite PhosphoSite-O43791
TrEMBL D6RIS7
UniProt Splice Variant
Entrez Gene 8405
UniGene
RefSeq XP_005257780
HUGO HGNC:11254
OMIM 602650
CCDS CCDS11551
HPRD 16004
IMGT
EMBL AC006487 AC015795 AJ000644 AK222589 AK293587 AK300616 AK312691 AK316366 BC001269 BC003385 CH471109
GenPept AAH01269 AAH03385 BAD96309 BAG35570 BAG57055 BAG62309 BAH14737 CAA04199 EAW94671 EAW94672 EAW94673 EAW94674 EAW94675

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca