Version 5.4
Homo sapiens Gene: SPOP
Summary
InnateDB Gene IDBG-57724.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPOP
Gene Name speckle-type POZ protein
Synonyms BTBD32; TEF2
Species Homo sapiens
Ensembl Gene ENSG00000121067
Encoded Proteins
IDBP-57726
speckle-type POZ protein
IDBP-243831
speckle-type POZ protein
IDBP-473591
speckle-type POZ protein
IDBP-480947
speckle-type POZ protein
IDBP-473386
speckle-type POZ protein
IDBP-479221
speckle-type POZ protein
IDBP-478548
speckle-type POZ protein
IDBP-480963
speckle-type POZ protein
IDBP-484688
speckle-type POZ protein
IDBP-476141
speckle-type POZ protein
IDBP-477431
speckle-type POZ protein
IDBP-483113
speckle-type POZ protein
IDBP-483801
speckle-type POZ protein
IDBP-474827
speckle-type POZ protein
IDBP-479586
speckle-type POZ protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:49598884-49678234
Strand Reverse strand
Band q21.33
Transcripts
ENST00000347630 ENSP00000240327
ENST00000393328 ENSP00000377001
ENST00000451526 ENSP00000423076
ENST00000504102 ENSP00000425905
ENST00000503676 ENSP00000420908
ENST00000507551
ENST00000504889
ENST00000509869 ENSP00000423284
ENST00000509079 ENSP00000426986
ENST00000505581 ENSP00000420960
ENST00000506399 ENSP00000425604
ENST00000507970 ENSP00000426262
ENST00000514121 ENSP00000424119
ENST00000515508 ENSP00000426537
ENST00000513080
ENST00000504212 ENSP00000422609
ENST00000510476 ENSP00000425410
ENST00000508805 ENSP00000427419
ENST00000502385
ENST00000509765
ENST00000572686
ENST00000577134
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 41 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
GO:0031463 Cul3-RING ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000057522
View Gene Order
ENSBTAG00000005824
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001007226 NM_001007227 NM_001007228 NM_001007229 NM_001007230 NM_003563
HUGO
OMIM
CCDS CCDS11551
HPRD 16004
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca