InnateDB Protein
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IDBP-473404.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC25A37
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Protein Name
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solute carrier family 25, member 37
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000429200
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InnateDB Gene
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IDBG-12031 (SLC25A37)
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Protein Structure
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Function |
Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity). {ECO:0000250}.
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Subcellular Localization |
Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005381
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iron ion transmembrane transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR018108
Mitochondrial substrate/solute carrier
IPR023395
Mitochondrial carrier domain
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PFAM |
PF00153
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NYZ2
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PhosphoSite |
PhosphoSite-Q9NYZ2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51312
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UniGene |
Hs.726050
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RefSeq |
NP_057696
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HUGO |
HGNC:29786
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OMIM |
610387
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CCDS |
CCDS47828
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HPRD |
17605
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IMGT |
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EMBL |
AF155660
AF223466
AK223194
AL833186
AY032628
BC015013
BC132799
BC132801
CH471080
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GenPept |
AAF64141
AAF67479
AAH15013
AAI32800
AAI32802
AAK38154
BAD96914
CAH10415
EAW63617
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