Version 5.4
Homo sapiens Protein: APBB2
Summary
InnateDB Protein IDBP-473826.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APBB2
Protein Name amyloid beta (A4) precursor protein-binding, family B, member 2
Synonyms FE65L; FE65L1;
Species Homo sapiens
Ensembl Protein ENSP00000426018
InnateDB Gene IDBG-15151 (APBB2)
Protein Structure
UniProt Annotation
Function May modulate the internalization of beta-amyloid precursor protein.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007050 cell cycle arrest
GO:0030308 negative regulation of cell growth
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030426 growth cone
GO:0045202 synapse
Protein Structure and Domains
PDB ID
InterPro IPR001202 WW domain
IPR006020 PTB/PI domain
PFAM PF00397
PF00640
PF14719
PRINTS
PIRSF
SMART SM00456
SM00462
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92870
PhosphoSite PhosphoSite-Q92870
TrEMBL D6RDY3
UniProt Splice Variant
Entrez Gene 323
UniGene Hs.734795
RefSeq NP_775098
HUGO HGNC:582
OMIM 602710
CCDS CCDS43224
HPRD 04088
IMGT
EMBL AC093804 AC096712 AC108937 AC131953 AK226179 AK295974 AK299800 BC027946 U62325
GenPept AAC50805 AAH27946 BAG58750 BAG61676

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca