InnateDB Protein
|
IDBP-473932.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
LSM6
|
Protein Name
|
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
|
Synonyms
|
YDR378C;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000420929
|
InnateDB Gene
|
IDBG-40113 (LSM6)
|
Protein Structure
|
|
Function |
Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:12515382}. Nucleus {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
38
[view]
|
Protein-Protein |
38
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001163
Ribonucleoprotein LSM domain
IPR006649
Ribonucleoprotein LSM domain, eukaryotic/archaea-type
IPR010920
Like-Sm (LSM) domain
|
PFAM |
PF01423
|
PRINTS |
|
PIRSF |
|
SMART |
SM00651
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P62312
|
PhosphoSite |
PhosphoSite-P62312
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
11157
|
UniGene |
Hs.190520
|
RefSeq |
|
HUGO |
HGNC:17017
|
OMIM |
607286
|
CCDS |
CCDS3767
|
HPRD |
06286
|
IMGT |
|
EMBL |
AC097372
AF182292
AJ238098
AK312126
BC016026
CH471056
|
GenPept |
AAD56230
AAH16026
AAY41032
BAG35062
CAB45869
EAX05029
EAX05030
EAX05031
|
|
|