Version 5.4
Homo sapiens Protein: GPX8
Summary
InnateDB Protein IDBP-474129.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPX8
Protein Name glutathione peroxidase 8 (putative)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000423822
InnateDB Gene IDBG-20980 (GPX8)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004601 peroxidase activity
GO:0004602 glutathione peroxidase activity
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006979 response to oxidative stress
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005788 endoplasmic reticulum lumen
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
IPR000889 Glutathione peroxidase
IPR012336 Thioredoxin-like fold
IPR013376 Glutathione peroxidase Gpx7, putative
PFAM PF00578
PF00255
PF13098
PF13192
PF13462
PF13905
PRINTS PR01011
PIRSF PIRSF000303
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TED1
PhosphoSite PhosphoSite-Q8TED1
TrEMBL
UniProt Splice Variant
Entrez Gene 493869
UniGene Hs.732562
RefSeq NP_001008398
HUGO HGNC:33100
OMIM
CCDS CCDS34156
HPRD 17416
IMGT
EMBL AC091977 AK074216 AY358715 BC029424 CH471123
GenPept AAH29424 AAQ89077 BAB85019 EAW54908

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca