Version 5.4
Homo sapiens Protein: SH3GLB1
Summary
InnateDB Protein IDBP-474200.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH3GLB1
Protein Name SH3-domain GRB2-like endophilin B1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000418744
InnateDB Gene IDBG-100094 (SH3GLB1)
Protein Structure
UniProt Annotation
Function May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. {ECO:0000269PubMed:11161816, ECO:0000269PubMed:11604418, ECO:0000269PubMed:15452144}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:15452144}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Mitochondrion outer membrane {ECO:0000269PubMed:15452144}; Peripheral membrane protein {ECO:0000269PubMed:15452144}. Note=Association with the Golgi apparatus depends on the cell type. {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes. {ECO:0000269PubMed:11161816, ECO:0000269PubMed:11259440}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 51 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006915 apoptotic process
GO:0032461 positive regulation of protein oligomerization
GO:0051259 protein oligomerization
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR004148 BAR domain
IPR011511 Variant SH3 domain
IPR018859 BAR domain-containing family
PFAM PF00018
PF14604
PF03114
PF07653
PF10455
PRINTS PR00452
PIRSF
SMART SM00326
SM00721
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y371
PhosphoSite PhosphoSite-Q9Y371
TrEMBL
UniProt Splice Variant
Entrez Gene 51100
UniGene Hs.136309
RefSeq NP_001193581
HUGO HGNC:10833
OMIM 609287
CCDS CCDS55612
HPRD 15333
IMGT
EMBL AB007960 AF151819 AF257318 AF263293 AF350371 AK001954 AK303710 AL049597 BC007455
GenPept AAD34056 AAF73017 AAF81225 AAH07455 AAK27365 BAA91999 BAD88797 BAG64694 CAC10394 CAC10395

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca