InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ELP3

Summary

InnateDB Protein

IDBP-474209.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ELP3

Protein Name

elongation protein 3 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000428449

InnateDB Gene

IDBG-14764 (ELP3)

Protein Structure

UniProt Annotation

Function

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May also have a methyltransferase activity. Involved in cell migration. {ECO:0000269PubMed:11714725, ECO:0000269PubMed:11818576, ECO:0000269PubMed:15902492, ECO:0000269PubMed:16713582}.

Subcellular Localization

Isoform 1: Nucleus.Isoform 2: Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	24 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0008080	N-acetyltransferase activity
GO:0008607	phosphorylase kinase regulator activity
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding

Biological Process

GO:0006325	chromatin organization
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0008152	metabolic process
GO:0016573	histone acetylation
GO:0030335	positive regulation of cell migration
GO:0045859	regulation of protein kinase activity

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0008023	transcription elongation factor complex
GO:0016591	DNA-directed RNA polymerase II, holoenzyme
GO:0033588	Elongator holoenzyme complex

Protein Structure and Domains

PDB ID

InterPro

IPR000182 GNAT domain
IPR005910 Histone acetyltransferase ELP3
IPR006638 Elongator protein 3/MiaB/NifB
IPR007197 Radical SAM
IPR016181 Acyl-CoA N-acyltransferase

PFAM

PF00583
PF13302
PF13508
PF13673
PF13718
PF04055

PRINTS

PIRSF

PIRSF005669

SMART

SM00729

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt