Homo sapiens Gene: ELP3
Summary
InnateDB Gene IDBG-14764.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELP3
Gene Name elongator acetyltransferase complex subunit 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134014
Encoded Proteins
elongation protein 3 homolog (S. cerevisiae)
elongation protein 3 homolog (S. cerevisiae)
elongation protein 3 homolog (S. cerevisiae)
elongation protein 3 homolog (S. cerevisiae)
elongation protein 3 homolog (S. cerevisiae)
elongation protein 3 homolog (S. cerevisiae)
elongation protein 3 homolog (S. cerevisiae)
elongation protein 3 homolog (S. cerevisiae)
elongation protein 3 homolog (S. cerevisiae)
elongation protein 3 homolog (S. cerevisiae)
elongation protein 3 homolog (S. cerevisiae)
elongation protein 3 homolog (S. cerevisiae)
elongation protein 3 homolog (S. cerevisiae)
elongation protein 3 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary ELP3 is the catalytic subunit of the histone acetyltransferase elongator complex, which contributes to transcript elongation and also regulates the maturation of projection neurons (Creppe et al., 2009 [PubMed 19185337]).[supplied by OMIM, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:28089673-28191156
Strand Forward strand
Band p21.1
Transcripts
ENST00000380353 ENSP00000369711
ENST00000256398 ENSP00000256398
ENST00000520270 ENSP00000429446
ENST00000521015 ENSP00000428449
ENST00000521570 ENSP00000428532
ENST00000523687 ENSP00000430253
ENST00000523760
ENST00000524103 ENSP00000429180
ENST00000518112 ENSP00000429465
ENST00000519261 ENSP00000428357
ENST00000521938
ENST00000520288 ENSP00000429248
ENST00000521099 ENSP00000429573
ENST00000522063
ENST00000520110
ENST00000520011
ENST00000523357 ENSP00000427833
ENST00000517975 ENSP00000430942
ENST00000537665 ENSP00000445558
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 24 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008080 N-acetyltransferase activity
GO:0008607 phosphorylase kinase regulator activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0006325 chromatin organization
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0008152 metabolic process
GO:0016573 histone acetylation
GO:0030335 positive regulation of cell migration
GO:0045859 regulation of protein kinase activity
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0008023 transcription elongation factor complex
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
GO:0033588 Elongator holoenzyme complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TCR pathway
REACTOME
HATs acetylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL E5RHY2 E5RIC0 E5RIZ7
UniProt Splice Variant
Entrez Gene 55140
UniGene Hs.491336 Hs.630929
RefSeq NM_001284220 NM_001284222 NM_001284224 NM_001284225 NM_001284226 NM_018091 XM_006716354
HUGO HGNC:20696
OMIM 612722
CCDS CCDS6065 CCDS64860 CCDS64861 CCDS75717 CCDS75718
HPRD 10936
IMGT
EMBL AC019031 AC021678
GenPept
RNA Seq Atlas 55140