InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD274

Summary

InnateDB Protein

IDBP-47493.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD274

Protein Name

CD274 molecule

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000370985

InnateDB Gene

IDBG-47487 (CD274)

Protein Structure

UniProt Annotation

Function

Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. {ECO:0000269PubMed:10581077, ECO:0000269PubMed:11015443}.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Endomembrane system; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. {ECO:0000269PubMed:10581077, ECO:0000269PubMed:11015443}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0031295	T cell costimulation
GO:0042102	positive regulation of T cell proliferation
GO:0045087	innate immune response (InnateDB)
GO:2001181	positive regulation of interleukin-10 secretion