Homo sapiens Gene: CD274
Summary
InnateDB Gene IDBG-47487.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD274
Gene Name CD274 molecule
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000120217
Encoded Proteins
CD274 molecule
CD274 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CD274 expression in macrophages is induced upon exposure to HIV virions and TLR stimulation. In addition, IL10 also up-regulates CD274 expression.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 9:5450503-5470566
Strand Forward strand
Band p24.1
Transcripts
ENST00000381577 ENSP00000370989
ENST00000381573 ENSP00000370985
ENST00000498261
ENST00000474218
ENST00000492923
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0031295 T cell costimulation
GO:0042102 positive regulation of T cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0045087 innate immune response (InnateDB)
GO:2001181 positive regulation of interleukin-10 secretion
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0012505 endomembrane system
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
PD-1 signaling pathway
Adaptive Immune System pathway
Immune System pathway
Costimulation by the CD28 family pathway
KEGG
Cell adhesion molecules (CAMs) pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.521989 Hs.712746
RefSeq NM_001267706 NM_014143
HUGO
OMIM
CCDS CCDS59118 CCDS6464
HPRD 05655
IMGT
EMBL
GenPept
RNA Seq Atlas