InnateDB Protein
|
IDBP-474996.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
DNAJC24
|
Protein Name
|
DnaJ (Hsp40) homolog, subfamily C, member 24
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000417548
|
InnateDB Gene
|
IDBG-37306 (DNAJC24)
|
Protein Structure
|
|
Function |
Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). {ECO:0000269PubMed:22367199, ECO:0000269PubMed:22509046}.
|
Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
Molecular Function |
|
Biological Process |
GO:0017183
|
peptidyl-diphthamide biosynthetic process from peptidyl-histidine
|
GO:0032781
|
positive regulation of ATPase activity
|
GO:0055114
|
oxidation-reduction process
|
GO:0061077
|
chaperone-mediated protein folding
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001623
DnaJ domain
IPR007872
Zinc finger, DPH-type
|
PFAM |
PF00226
PF05207
|
PRINTS |
PR00625
|
PIRSF |
|
SMART |
SM00271
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q6P3W2
|
PhosphoSite |
PhosphoSite-Q6P3W2
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
120526
|
UniGene |
Hs.613612
|
RefSeq |
NP_859057
|
HUGO |
HGNC:26979
|
OMIM |
611072
|
CCDS |
CCDS7873
|
HPRD |
15705
|
IMGT |
|
EMBL |
AK289665
AL137804
BC063804
CH471064
|
GenPept |
AAH63804
BAF82354
EAW68245
|
|
|