Homo sapiens Gene: DNAJC24
Summary
InnateDB Gene IDBG-37306.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNAJC24
Gene Name DnaJ (Hsp40) homolog, subfamily C, member 24
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000170946
Encoded Proteins
DnaJ (Hsp40) homolog, subfamily C, member 24
DnaJ (Hsp40) homolog, subfamily C, member 24
DnaJ (Hsp40) homolog, subfamily C, member 24
DnaJ (Hsp40) homolog, subfamily C, member 24
DnaJ (Hsp40) homolog, subfamily C, member 24
DnaJ (Hsp40) homolog, subfamily C, member 24
DnaJ (Hsp40) homolog, subfamily C, member 24
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:31369840-31432832
Strand Forward strand
Band p13
Transcripts
ENST00000395949 ENSP00000379279
ENST00000465995 ENSP00000417548
ENST00000527601
ENST00000529086
ENST00000532385
ENST00000525511 ENSP00000432072
ENST00000526042 ENSP00000435771
ENST00000526529 ENSP00000434114
ENST00000527731 ENSP00000432388
ENST00000530125
ENST00000524747
ENST00000536040 ENSP00000444967
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001671 ATPase activator activity
GO:0008198 ferrous iron binding
GO:0008270 zinc ion binding
Biological Process
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine
GO:0032781 positive regulation of ATPase activity
GO:0055114 oxidation-reduction process
GO:0061077 chaperone-mediated protein folding
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL D3DQZ6 I6L9B4
UniProt Splice Variant
Entrez Gene 120526
UniGene Hs.187269 Hs.613612
RefSeq NM_181706
HUGO HGNC:26979
OMIM 611072
CCDS CCDS7873
HPRD 15705
IMGT
EMBL AC108456 AL137804 BC036571 CH471064
GenPept AAH36571 EAW68243 EAW68244
RNA Seq Atlas 120526