InnateDB Protein
|
IDBP-475432.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
CARD8
|
Protein Name
|
caspase recruitment domain family, member 8
|
Synonyms
|
CARDINAL; DACAR; DAKAR; NDPP; NDPP1; TUCAN;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000428736
|
InnateDB Gene
|
IDBG-60120 (CARD8)
|
Protein Structure
|
|
Function |
|
Subcellular Localization |
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
21
[view]
|
Protein-Protein |
19
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
1
[view]
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0005515
|
protein binding
|
GO:0008656
|
cysteine-type endopeptidase activator activity involved in apoptotic process
|
GO:0032089
|
NACHT domain binding
|
GO:0042803
|
protein homodimerization activity
|
|
Biological Process |
GO:0006919
|
activation of cysteine-type endopeptidase activity involved in apoptotic process
|
GO:0042981
|
regulation of apoptotic process
|
GO:0043124
|
negative regulation of I-kappaB kinase/NF-kappaB signaling
|
GO:0043280
|
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
|
GO:0050718
|
positive regulation of interleukin-1 beta secretion
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001315
CARD domain
IPR011029
Death-like domain
|
PFAM |
PF00619
|
PRINTS |
|
PIRSF |
|
SMART |
SM00114
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9Y2G2
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
E5RJG3
|
UniProt Splice Variant |
|
Entrez Gene |
22900
|
UniGene |
Hs.68846
|
RefSeq |
NP_055774
|
HUGO |
HGNC:17057
|
OMIM |
609051
|
CCDS |
CCDS12712
|
HPRD |
16425
|
IMGT |
|
EMBL |
AB023172
AC008392
AC011466
AF322184
AF331519
AF405558
AF511652
AK297045
AK297069
AY026322
BC056891
CH471177
EU118120
|
GenPept |
AAG50014
AAH56891
AAK01126
AAK08982
AAL02427
AAM46959
ABW96891
BAA76799
BAH12482
BAH12488
EAW52321
EAW52323
|
|
|