InnateDB Protein
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IDBP-475893.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TIPARP
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Protein Name
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TCDD-inducible poly(ADP-ribose) polymerase
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Synonyms
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ARTD14; PARP7; pART14;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000418757
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InnateDB Gene
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IDBG-62730 (TIPARP)
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Protein Structure
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Function |
Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity). {ECO:0000250}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0010629
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negative regulation of gene expression
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GO:0045732
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positive regulation of protein catabolic process
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GO:0071407
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cellular response to organic cyclic compound
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Cellular Component |
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PDB ID |
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InterPro |
IPR004170
WWE domain
IPR012317
Poly(ADP-ribose) polymerase, catalytic domain
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PFAM |
PF02825
PF00644
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q7Z3E1
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PhosphoSite |
PhosphoSite-Q7Z3E1
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TrEMBL |
G5E9W1
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UniProt Splice Variant |
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Entrez Gene |
25976
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UniGene |
Hs.630820
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RefSeq |
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HUGO |
HGNC:23696
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OMIM |
612480
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CCDS |
CCDS3177
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HPRD |
18192
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IMGT |
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EMBL |
AC092927
AC106708
AL080156
BC050350
BX537965
CH471052
CR749647
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GenPept |
AAH50350
CAB45747
CAD97929
CAH18441
EAW78725
EAW78726
EAW78727
EAW78728
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