InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WDR36

Summary

InnateDB Protein

IDBP-476115.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WDR36

Protein Name

WD repeat domain 36

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000423067

InnateDB Gene

IDBG-36607 (WDR36)

Protein Structure

UniProt Annotation

Function

Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2. {ECO:0000269PubMed:21051332}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:21051332, ECO:0000269PubMed:22002106}.

Disease Associations

Glaucoma 1, open angle, G (GLC1G) [MIM:609887]: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. {ECO:0000269PubMed:15677485}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. In ocular tissues, strong expression in iris, sclera, ciliary muscle, ciliary body, retina and optic nerve. {ECO:0000269PubMed:15677485}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001895	retina homeostasis
GO:0006364	rRNA processing
GO:0007601	visual perception
GO:0008150	biological_process
GO:0030516	regulation of axon extension
GO:0050896	response to stimulus

Cellular Component

GO:0005575	cellular_component
GO:0005730	nucleolus
GO:0032040	small-subunit processome

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR007319 Small-subunit processome, Utp21
IPR011047 Quinonprotein alcohol dehydrogenase-like superfamily
IPR017986 WD40-repeat-containing domain

PFAM

PF00400
PF04192

PRINTS

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8NI36