InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WDR36

Summary

InnateDB Gene

IDBG-36607.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WDR36

Gene Name

WD repeat domain 36

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000134987

Encoded Proteins

IDBP-476115

WD repeat domain 36

IDBP-478081

WD repeat domain 36

IDBP-806374

WD repeat domain 36

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:111091716-111130502

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000506538	ENSP00000423067
ENST00000513710	ENSP00000424628
ENST00000505303
ENST00000515784
ENST00000504122
ENST00000612402	ENSP00000479950

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001895	retina homeostasis
GO:0006364	rRNA processing
GO:0007601	visual perception
GO:0008150	biological_process
GO:0030516	regulation of axon extension
GO:0050896	response to stimulus

Cellular Component

GO:0005575	cellular_component
GO:0005730	nucleolus
GO:0032040	small-subunit processome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038299

View Gene Order

ENSBTAG00000005489

Not yet available

Pathways

NETPATH

NetPath_24

TSLP pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.533237 Hs.706546

RefSeq

NM_139281

HUGO

OMIM

CCDS

CCDS4102

HPRD

10305

IMGT

EMBL

GenPept

RNA Seq Atlas