InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MITF

Summary

InnateDB Protein

IDBP-476311.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MITF

Protein Name

microphthalmia-associated transcription factor

Synonyms

bHLHe32; CMM8; MI; WS2; WS2A;

Species

Homo sapiens

Ensembl Protein

ENSP00000418845

InnateDB Gene

IDBG-44086 (MITF)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	30 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006461	protein complex assembly
GO:0030318	melanocyte differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter