InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AADAT

Summary

InnateDB Protein

IDBP-476322.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AADAT

Protein Name

aminoadipate aminotransferase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000423190

InnateDB Gene

IDBG-44521 (AADAT)

Protein Structure

UniProt Annotation

Function

Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino- group acceptors, with a preference for 2-oxoglutarate, 2- oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro). {ECO:0000269PubMed:18620547}.

Subcellular Localization

Mitochondrion {ECO:0000305}.

Disease Associations

Tissue Specificity

Higher expression in the liver. Also found in heart, brain, kidney, pancreas, prostate, testis and ovary.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016212	kynurenine-oxoglutarate transaminase activity
GO:0030170	pyridoxal phosphate binding
GO:0042803	protein homodimerization activity
GO:0047536	2-aminoadipate transaminase activity

Biological Process

GO:0006103	2-oxoglutarate metabolic process
GO:0006536	glutamate metabolic process
GO:0006554	lysine catabolic process
GO:0006569	tryptophan catabolic process
GO:0009058	biosynthetic process
GO:0019441	tryptophan catabolic process to kynurenine
GO:0033512	L-lysine catabolic process to acetyl-CoA via saccharopine
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0070189	kynurenine metabolic process
GO:0097052	L-kynurenine metabolic process