InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HHLA2

Summary

InnateDB Protein

IDBP-476342.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HHLA2

Protein Name

HERV-H LTR-associating 2

Synonyms

B7H7;

Species

Homo sapiens

Ensembl Protein

ENSP00000417856

InnateDB Gene

IDBG-48892 (HHLA2)

Protein Structure

UniProt Annotation

Function

Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. {ECO:0000269PubMed:23784006}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at high levels in colon, kidney, testis, lung and pancreas, and at lower levels in small intestine, liver and skeletal muscle. In immune cells, highly expressed in B- cells, dendritic cells and macrophages. Not detected in T-cells. {ECO:0000269PubMed:10444326, ECO:0000269PubMed:23784006}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0001819	positive regulation of cytokine production
GO:0031295	T cell costimulation
GO:0042104	positive regulation of activated T cell proliferation

Cellular Component

GO:0005575	cellular_component
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003597 Immunoglobulin C1-set
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain

PFAM

PF07654
PF07686

PRINTS

PIRSF

SMART

SM00406
SM00407
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UM44