Version 5.4
Homo sapiens Gene: HHLA2
Summary
InnateDB Gene IDBG-48892.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HHLA2
Gene Name HERV-H LTR-associating 2
Synonyms B7H7
Species Homo sapiens
Ensembl Gene ENSG00000114455
Encoded Proteins
IDBP-48894
HERV-H LTR-associating 2
IDBP-479642
HERV-H LTR-associating 2
IDBP-481848
HERV-H LTR-associating 2
IDBP-474398
HERV-H LTR-associating 2
IDBP-484104
HERV-H LTR-associating 2
IDBP-481085
HERV-H LTR-associating 2
IDBP-485317
HERV-H LTR-associating 2
IDBP-481447
HERV-H LTR-associating 2
IDBP-476342
HERV-H LTR-associating 2
IDBP-478601
HERV-H LTR-associating 2
IDBP-811732
HERV-H LTR-associating 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:108296490-108378285
Strand Forward strand
Band q13.13
Transcripts
ENST00000357759 ENSP00000350402
ENST00000467282 ENSP00000420622
ENST00000463019 ENSP00000419940
ENST00000491820 ENSP00000418284
ENST00000467562 ENSP00000418345
ENST00000482430 ENSP00000418174
ENST00000462629 ENSP00000419911
ENST00000467761 ENSP00000419207
ENST00000489514 ENSP00000417856
ENST00000482099 ENSP00000418797
ENST00000619531 ENSP00000482187
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0001819 positive regulation of cytokine production
GO:0031295 T cell costimulation
GO:0042104 positive regulation of activated T cell proliferation
Cellular Component
GO:0005575 cellular_component
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9UM44
TrEMBL C9J8J7 C9JD07 C9JY13 C9JY43
UniProt Splice Variant
Entrez Gene 11148
UniGene Hs.252351 Hs.639016
RefSeq NM_001282556 NM_001282557 NM_001282558 NM_001282559 NM_007072 XM_005247080
HUGO HGNC:4905
OMIM 604371
CCDS CCDS46883 CCDS63713 CCDS74975
HPRD 05082
IMGT
EMBL AC078855 AC135308 AF126162 AK000692 AK296644 BC035971 CH471052
GenPept AAD48396 AAH35971 BAA91323 BAG59244 EAW79727 EAW79728
RNA Seq Atlas 11148

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca