InnateDB Protein
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IDBP-476395.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC27A6
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Protein Name
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solute carrier family 27 (fatty acid transporter), member 6
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000421024
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InnateDB Gene
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IDBG-40136 (SLC27A6)
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Protein Structure
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Function |
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart. {ECO:0000269PubMed:12556534}.
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Subcellular Localization |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane, sarcolemma {ECO:0000250}. Note=In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Strongly expressed in heart and localizes to cardiac myocytes. Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus. {ECO:0000269PubMed:12556534}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000873
AMP-dependent synthetase/ligase
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PFAM |
PF00501
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y2P4
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PhosphoSite |
PhosphoSite-Q9Y2P4
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TrEMBL |
D6RAJ2
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UniProt Splice Variant |
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Entrez Gene |
28965
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UniGene |
Hs.733430
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RefSeq |
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HUGO |
HGNC:11000
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OMIM |
604196
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CCDS |
CCDS4145
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HPRD |
09173
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IMGT |
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EMBL |
AC004038
AC004636
AC006959
AC008588
AC113387
AC114276
AF064254
BC041945
BX537383
CR457129
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GenPept |
AAD29443
AAH41945
CAD97625
CAG33410
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