InnateDB Protein
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IDBP-476545.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CADPS
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Protein Name
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Ca++-dependent secretion activator
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Synonyms
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CADPS1; CAPS; CAPS1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000418736
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InnateDB Gene
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IDBG-42670 (CADPS)
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Protein Structure
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Function |
Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to DCVs but not to SVs. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2 (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Specifically expressed in neural and endocrine secretory tissues. Expressed in brain and pancreas and at low level in heart. Also expressed in fetal heart, cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobes, and putamen, as well as weak expression in spinal cord. {ECO:0000269PubMed:12659812}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9ULU8
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PhosphoSite |
PhosphoSite-Q9ULU8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
8618
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UniGene |
Hs.654933
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RefSeq |
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HUGO |
HGNC:1426
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OMIM |
604667
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CCDS |
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HPRD |
05236
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IMGT |
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EMBL |
AB032947
AC104161
AF458662
AL833895
BC015754
BC029460
BC072684
U36448
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GenPept |
AAA79701
AAH15754
AAH29460
AAH72684
AAM61861
BAA86435
CAD38751
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