Version 5.4
Homo sapiens Gene: CADPS
Summary
InnateDB Gene IDBG-42670.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CADPS
Gene Name Ca++-dependent secretion activator
Synonyms CADPS1; CAPS; CAPS1
Species Homo sapiens
Ensembl Gene ENSG00000163618
Encoded Proteins
IDBP-42672
Ca++-dependent secretion activator
IDBP-42674
Ca++-dependent secretion activator
IDBP-42680
Ca++-dependent secretion activator
IDBP-481271
Ca++-dependent secretion activator
IDBP-476588
Ca++-dependent secretion activator
IDBP-485346
Ca++-dependent secretion activator
IDBP-480195
Ca++-dependent secretion activator
IDBP-476819
Ca++-dependent secretion activator
IDBP-476545
Ca++-dependent secretion activator
IDBP-584854
Ca++-dependent secretion activator
IDBP-806469
Ca++-dependent secretion activator
IDBP-806470
Ca++-dependent secretion activator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:62398346-62875389
Strand Reverse strand
Band p14.2
Transcripts
ENST00000383710 ENSP00000373215
ENST00000357948 ENSP00000350632
ENST00000283269 ENSP00000283269
ENST00000486172
ENST00000473635 ENSP00000418889
ENST00000474560
ENST00000466621 ENSP00000417568
ENST00000469292
ENST00000462768
ENST00000478408
ENST00000478570
ENST00000463002
ENST00000491424 ENSP00000418110
ENST00000468271 ENSP00000417827
ENST00000478434 ENSP00000420044
ENST00000490424
ENST00000490353 ENSP00000418736
ENST00000542833 ENSP00000439528
ENST00000612439 ENSP00000484365
ENST00000613879 ENSP00000482556
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0019901 protein kinase binding
GO:0046872 metal ion binding
Biological Process
GO:0006887 exocytosis
GO:0015031 protein transport
GO:0016050 vesicle organization
GO:0016082 synaptic vesicle priming
GO:0050432 catecholamine secretion
Cellular Component
GO:0005829 cytosol
GO:0030054 cell junction
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054423
View Gene Order
ENSBTAG00000005321
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 8618
UniGene Hs.654933
RefSeq NM_003716 NM_183393 NM_183394 XM_006713368 XM_006713369 XM_006713370 XM_006713371 XM_006713372
HUGO HGNC:1426
OMIM 604667
CCDS CCDS2898 CCDS2899 CCDS46858
HPRD 05236
IMGT
EMBL
GenPept
RNA Seq Atlas 8618

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca