InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UGT2A1

Summary

InnateDB Protein

IDBP-476558.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UGT2A1

Protein Name

UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000424478

InnateDB Gene

IDBG-21898 (UGT2A1)

Protein Structure

UniProt Annotation

Function

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium. {ECO:0000269PubMed:19858781}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Olfactory epithelium and brain. Isoform 2 is mainly expressed in the nasal mucosa. {ECO:0000269PubMed:10359671, ECO:0000269PubMed:19858781}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015020	glucuronosyltransferase activity
GO:0016758	transferase activity, transferring hexosyl groups
GO:0030246	carbohydrate binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0007608	sensory perception of smell
GO:0008152	metabolic process
GO:0009593	detection of chemical stimulus
GO:0030259	lipid glycosylation
GO:0052695	cellular glucuronidation