InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNASET2

Summary

InnateDB Protein

IDBP-476634.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNASET2

Protein Name

ribonuclease T2

Synonyms

bA514O12.3; RNASE6PL;

Species

Homo sapiens

Ensembl Protein

ENSP00000422846

InnateDB Gene

IDBG-98984 (RNASET2)

Protein Structure

UniProt Annotation

Function

Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism. {ECO:0000250, ECO:0000269PubMed:16620762, ECO:0000269PubMed:19525954, ECO:0000269PubMed:22735700}.

Subcellular Localization

Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Note=Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction.

Disease Associations

Leukoencephalopathy, cystic, without megalencephaly (LCWM) [MIM:612951]: An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications. {ECO:0000269PubMed:19525954}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain. {ECO:0000269PubMed:19525954}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004540	ribonuclease activity
GO:0033897	ribonuclease T2 activity

Biological Process

GO:0006401	RNA catabolic process
GO:0090501	RNA phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005764	lysosome
GO:0005788	endoplasmic reticulum lumen
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome