InnateDB Protein
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IDBP-477028.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TNIP1
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Protein Name
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TNFAIP3 interacting protein 1
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Synonyms
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ABIN-1; NAF1; nip40-1; VAN;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000430971
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InnateDB Gene
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IDBG-54098 (TNIP1)
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Protein Structure
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Function |
Inhibits NF-kappa-B activation and TNF-induced NF-kappa- B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti- inflammatory response of macrophages and positively regulates TLR- induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. {ECO:0000269PubMed:12220502, ECO:0000269PubMed:16684768, ECO:0000269PubMed:17016622, ECO:0000269PubMed:17632516, ECO:0000269PubMed:20010814}.
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Subcellular Localization |
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. In peripheral blood mononucleocytes, isoform 4 is mainly expressed and isoform 1 and isoform 7 are almost not expressed. Expression of isoform 1 and isoform 7 increases in leukemic cells. {ECO:0000269PubMed:17016622}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
63
[view]
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Protein-Protein |
57
[view]
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Protein-DNA |
5
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
1
[view]
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0002755
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MyD88-dependent toll-like receptor signaling pathway
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GO:0006412
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translation
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GO:0006952
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defense response
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GO:0006954
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inflammatory response
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GO:0007159
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leukocyte cell-cell adhesion
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GO:0009101
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glycoprotein biosynthetic process
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GO:0043124
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negative regulation of I-kappaB kinase/NF-kappaB signaling
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GO:0045071
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negative regulation of viral genome replication
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GO:0045087
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innate immune response (InnateDB)
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0050729
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positive regulation of inflammatory response
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GO:0070373
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negative regulation of ERK1 and ERK2 cascade
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GO:0085032
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modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
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Cellular Component |
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PDB ID |
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InterPro |
IPR016024
Armadillo-type fold
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q15025
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PhosphoSite |
PhosphoSite-Q15025
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TrEMBL |
E7EWG2
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UniProt Splice Variant |
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Entrez Gene |
10318
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UniGene |
Hs.719365
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RefSeq |
NP_001239322
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HUGO |
HGNC:16903
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OMIM |
607714
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CCDS |
CCDS58985
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HPRD |
09216
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IMGT |
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EMBL |
AB177543
AB177544
AB252970
AB252971
AB252972
AB252973
AB252974
AB252975
AB252976
AB252977
AB252978
AB252979
AB252980
AB252981
AC008641
AJ011895
AJ011896
AK299975
AY012155
BC012133
BC014008
BX640647
CH471062
D30755
U39403
U83844
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GenPept |
AAB41438
AAC99999
AAG42154
AAH12133
AAH14008
BAA06416
BAF34946
BAF34947
BAF48787
BAF48788
BAF48789
BAF48790
BAF48791
BAF48792
BAF48793
BAF48794
BAF48795
BAF48796
BAF48797
BAF48798
BAH13185
CAA09855
CAA09856
CAE45793
EAW61688
EAW61689
EAW61690
EAW61691
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