InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TNIP1

Summary

InnateDB Gene

IDBG-54098.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNIP1

Gene Name

TNFAIP3 interacting protein 1

Synonyms

ABIN-1; NAF1; nip40-1; VAN

Species

Homo sapiens

Ensembl Gene

ENSG00000145901

Encoded Proteins

IDBP-54100

TNFAIP3 interacting protein 1

IDBP-54102

TNFAIP3 interacting protein 1

IDBP-484643

TNFAIP3 interacting protein 1

IDBP-482561

TNFAIP3 interacting protein 1

IDBP-484997

TNFAIP3 interacting protein 1

IDBP-482289

TNFAIP3 interacting protein 1

IDBP-475182

TNFAIP3 interacting protein 1

IDBP-484093

TNFAIP3 interacting protein 1

IDBP-477028

TNFAIP3 interacting protein 1

IDBP-473389

TNFAIP3 interacting protein 1

IDBP-482296

TNFAIP3 interacting protein 1

IDBP-475861

TNFAIP3 interacting protein 1

IDBP-480051

TNFAIP3 interacting protein 1

IDBP-483863

TNFAIP3 interacting protein 1

IDBP-808754

TNFAIP3 interacting protein 1

IDBP-808765

TNFAIP3 interacting protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21606507

TNIP1 interacts with polyubiquitin to limit the activation of TLR-MYD88 signalling pathway and prevents autoimmunity. (Demonstrated in murine model)

PMID 22011580

TNIP1 is an essential anti-inflammatory component of TLR-signalling pathways that controls CEBPB activity. Tnip1 null mice exhibit progressive, lupus-like inflammatory disease. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 21606507

[Mus musculus] Tnip1 interacts with polyubiquitin to limit the activation of Tlr-Myd88 signalling pathway and prevents autoimmunity.

PMID 22011580

[Mus musculus] Tnip1 is an essential anti-inflammatory component of TLR-signalling pathways that controls Cebpb activity. Tnip1 null mice exhibit progressive, lupus-like inflammatory disease.

Entrez Gene

Summary

This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:151029945-151093577

Strand

Reverse strand

Band

q33.1

Transcripts

ENST00000315050	ENSP00000317891
ENST00000389378	ENSP00000374029
ENST00000520931	ENSP00000429891
ENST00000517504	ENSP00000430739
ENST00000523338	ENSP00000428243
ENST00000522574
ENST00000522226	ENSP00000428187
ENST00000519339	ENSP00000427854
ENST00000521591	ENSP00000430760
ENST00000518977	ENSP00000430971
ENST00000524280	ENSP00000429912
ENST00000523200	ENSP00000431105
ENST00000521423
ENST00000517329
ENST00000521782
ENST00000522100	ENSP00000428487
ENST00000520695	ENSP00000430279
ENST00000521001	ENSP00000428404
ENST00000522926
ENST00000610874	ENSP00000484665
ENST00000610535	ENSP00000483944

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	57 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0005488	binding
GO:0005515	protein binding
GO:0051019	mitogen-activated protein kinase binding

Biological Process

GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006412	translation
GO:0006952	defense response
GO:0006954	inflammatory response
GO:0007159	leukocyte cell-cell adhesion
GO:0009101	glycoprotein biosynthetic process
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050729	positive regulation of inflammatory response
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0085032	modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020400

View Gene Order

ENSBTAG00000012671

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q15025

TrEMBL

E7EW15 E7EW68 E7EWG2

UniProt Splice Variant

Entrez Gene

10318

UniGene

Hs.355141 Hs.719365

RefSeq

NM_001252392 NM_001252385 NM_001252386 NM_001252390 NM_001252391 NM_001252393 NM_001258454 NM_001258455 NM_001258456 NM_006058 XM_005268355 XM_006714751

HUGO

HGNC:16903

OMIM

607714

CCDS

CCDS58985 CCDS34280 CCDS58982 CCDS58983 CCDS58984 CCDS75359

HPRD

09216

IMGT

EMBL

AB177543 AB177544 AB252970 AB252971 AB252972 AB252973 AB252974 AB252975 AB252976 AB252977 AB252978 AB252979 AB252980 AB252981 AC008641 AJ011895 AJ011896 AK299975 AY012155 BC012133 BC014008 BX640647 CH471062 D30755 U39403 U83844

GenPept

AAB41438 AAC99999 AAG42154 AAH12133 AAH14008 BAA06416 BAF34946 BAF34947 BAF48787 BAF48788 BAF48789 BAF48790 BAF48791 BAF48792 BAF48793 BAF48794 BAF48795 BAF48796 BAF48797 BAF48798 BAH13185 CAA09855 CAA09856 CAE45793 EAW61688 EAW61689 EAW61690 EAW61691

RNA Seq Atlas

10318