Homo sapiens Gene: TNIP1
Summary
InnateDB Gene IDBG-54098.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNIP1
Gene Name TNFAIP3 interacting protein 1
Synonyms ABIN-1; NAF1; nip40-1; VAN;
Species Homo sapiens
Ensembl Gene ENSG00000145901
Encoded Proteins
TNFAIP3 interacting protein 1
TNFAIP3 interacting protein 1
TNFAIP3 interacting protein 1
TNFAIP3 interacting protein 1
TNFAIP3 interacting protein 1
TNFAIP3 interacting protein 1
TNFAIP3 interacting protein 1
TNFAIP3 interacting protein 1
TNFAIP3 interacting protein 1
TNFAIP3 interacting protein 1
TNFAIP3 interacting protein 1
TNFAIP3 interacting protein 1
TNFAIP3 interacting protein 1
TNFAIP3 interacting protein 1
TNFAIP3 interacting protein 1
TNFAIP3 interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
TNIP1 interacts with polyubiquitin to limit the activation of TLR-MYD88 signalling pathway and prevents autoimmunity. (Demonstrated in murine model)
TNIP1 is an essential anti-inflammatory component of TLR-signalling pathways that controls CEBPB activity. Tnip1 null mice exhibit progressive, lupus-like inflammatory disease. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Tnip1 interacts with polyubiquitin to limit the activation of Tlr-Myd88 signalling pathway and prevents autoimmunity.
[Mus musculus] Tnip1 is an essential anti-inflammatory component of TLR-signalling pathways that controls Cebpb activity. Tnip1 null mice exhibit progressive, lupus-like inflammatory disease.
Entrez Gene
Summary This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:151029945-151093577
Strand Reverse strand
Band q33.1
Transcripts
ENST00000315050 ENSP00000317891
ENST00000389378 ENSP00000374029
ENST00000520931 ENSP00000429891
ENST00000517504 ENSP00000430739
ENST00000523338 ENSP00000428243
ENST00000522574
ENST00000522226 ENSP00000428187
ENST00000519339 ENSP00000427854
ENST00000521591 ENSP00000430760
ENST00000518977 ENSP00000430971
ENST00000524280 ENSP00000429912
ENST00000523200 ENSP00000431105
ENST00000521423
ENST00000517329
ENST00000521782
ENST00000522100 ENSP00000428487
ENST00000520695 ENSP00000430279
ENST00000521001 ENSP00000428404
ENST00000522926
ENST00000610874 ENSP00000484665
ENST00000610535 ENSP00000483944
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 63 [view]
Protein-Protein 57 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0005488 binding
GO:0005515 protein binding
GO:0051019 mitogen-activated protein kinase binding
Biological Process
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0006412 translation
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007159 leukocyte cell-cell adhesion
GO:0009101 glycoprotein biosynthetic process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050729 positive regulation of inflammatory response
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0085032 modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.355141 Hs.719365
RefSeq NM_001252385 NM_001252386 NM_001252390 NM_001252391 NM_001252392 NM_001252393 NM_001258454 NM_001258455 NM_001258456 NM_006058 XM_005268355 XM_006714751
HUGO
OMIM
CCDS CCDS34280 CCDS58982 CCDS58983 CCDS58984 CCDS58985 CCDS75359
HPRD 09216
IMGT
EMBL
GenPept
RNA Seq Atlas