Homo sapiens Protein: TNIK | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-477215.4 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | TNIK | ||||||||||||||||||||||
Protein Name | TRAF2 and NCK interacting kinase | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000419990 | ||||||||||||||||||||||
InnateDB Gene | IDBG-64741 (TNIK) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. {ECO:0000269PubMed:10521462, ECO:0000269PubMed:15342639, ECO:0000269PubMed:19061864, ECO:0000269PubMed:19816403, ECO:0000269PubMed:20159449, ECO:0000269PubMed:21690388}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues. {ECO:0000269PubMed:10521462, ECO:0000269PubMed:19816403}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR001180 Citron-like IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00069
PF00780 PF07714 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||||||
SMART |
SM00036
SM00220 SM00219 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q9UKE5 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q9UKE5 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 23043 | ||||||||||||||||||||||
UniGene | Hs.34024 | ||||||||||||||||||||||
RefSeq | NP_001155034 | ||||||||||||||||||||||
HUGO | HGNC:30765 | ||||||||||||||||||||||
OMIM | 610005 | ||||||||||||||||||||||
CCDS | CCDS54675 | ||||||||||||||||||||||
HPRD | 18206 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB011123 AC026315 AC078793 AC092919 AC137517 AF172264 AF172265 AF172266 AF172267 AF172268 AF172269 AF172270 AF172271 AK291056 BC019081 BC150256 CH471052 | ||||||||||||||||||||||
GenPept | AAF03782 AAF03783 AAF03784 AAF03785 AAF03786 AAF03787 AAF03788 AAF03789 AAH19081 AAI50257 BAA25477 BAF83745 EAW78484 EAW78489 EAW78492 EAW78493 | ||||||||||||||||||||||