InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TNIK

Summary

InnateDB Gene

IDBG-64741.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNIK

Gene Name

TRAF2 and NCK interacting kinase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000154310

Encoded Proteins

IDBP-64743

TRAF2 and NCK interacting kinase

IDBP-64747

TRAF2 and NCK interacting kinase

IDBP-64749

TRAF2 and NCK interacting kinase

IDBP-385340

TRAF2 and NCK interacting kinase

IDBP-475446

TRAF2 and NCK interacting kinase

IDBP-482987

TRAF2 and NCK interacting kinase

IDBP-477655

TRAF2 and NCK interacting kinase

IDBP-477215

TRAF2 and NCK interacting kinase

IDBP-483839

TRAF2 and NCK interacting kinase

IDBP-482404

TRAF2 and NCK interacting kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:171061339-171460408

Strand

Reverse strand

Band

q26.31

Transcripts

ENST00000284483	ENSP00000284483
ENST00000357327	ENSP00000349880
ENST00000341852	ENSP00000345352
ENST00000436636	ENSP00000399511
ENST00000496492
ENST00000464785
ENST00000475336	ENSP00000418156
ENST00000460047	ENSP00000418916
ENST00000488470	ENSP00000418378
ENST00000470834	ENSP00000419990
ENST00000484051
ENST00000487846
ENST00000459881
ENST00000468757	ENSP00000417338
ENST00000465393	ENSP00000419308

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	48 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007010	cytoskeleton organization
GO:0007256	activation of JNKK activity
GO:0016055	Wnt signaling pathway
GO:0031532	actin cytoskeleton reorganization
GO:0035556	intracellular signal transduction
GO:0046777	protein autophosphorylation
GO:0048814	regulation of dendrite morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0055037	recycling endosome
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027692

View Gene Order

ENSBTAG00000011742

Not yet available

Pathways

NETPATH

REACTOME

REACT_120956

Cellular responses to stress pathway

REACT_169274

Cellular Senescence pathway

REACT_169436

Oxidative Stress Induced Senescence pathway

KEGG

INOH

PID NCI

betacatenin_nuc_pathway

Regulation of nuclear beta catenin signaling and target gene transcription

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.34024

RefSeq

NM_001161560 NM_001161561 NM_001161562 NM_001161563 NM_001161564 NM_001161565 NM_001161566 NM_015028 XM_006713555

HUGO

OMIM

CCDS

CCDS46956 CCDS54673 CCDS54674 CCDS54675 CCDS54676 CCDS54677 CCDS54678 CCDS54679

HPRD

18206

IMGT

EMBL

GenPept

RNA Seq Atlas