Version 5.4
Homo sapiens Protein: HTR4
Summary
InnateDB Protein IDBP-477454.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HTR4
Protein Name 5-hydroxytryptamine (serotonin) receptor 4
Synonyms 5-HT4; 5-HT4R;
Species Homo sapiens
Ensembl Protein ENSP00000427913
InnateDB Gene IDBG-52561 (HTR4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004993 serotonin receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007210 serotonin receptor signaling pathway
GO:0007268 synaptic transmission
GO:0008284 positive regulation of cell proliferation
GO:0032098 regulation of appetite
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001520 5-Hydroxytryptamine 4 receptor
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PR01059
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13639
PhosphoSite PhosphoSite-Q13639
TrEMBL
UniProt Splice Variant
Entrez Gene 3360
UniGene Hs.483773
RefSeq NP_001273339
HUGO HGNC:5299
OMIM 602164
CCDS CCDS75353
HPRD
IMGT
EMBL AC008627 AC011390 AC091971 AC114939 AJ011371 AJ131724 AJ131725 AJ131726 AJ243213 AJ278979 AJ278980 AJ278981 AJ278982 AJ633645 AM712912 BC074755 BC095497 CH471062 Y08756 Y09586 Y10437 Y12505 Y12506 Y12507 Y13584 Z48150
GenPept AAH74755 AAH95497 CAA09600 CAA70002 CAA70774 CAA71462 CAA73107 CAA73108 CAA73109 CAA73911 CAA88167 CAB71316 CAC20411 CAC22248 CAC22249 CAC22250 CAC22251 CAC79533 CAC79538 CAG17627 CAN84676 EAW61800 EAW61801 EAW61804

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca