Version 5.4
Homo sapiens Gene: HTR4
Summary
InnateDB Gene IDBG-52561.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HTR4
Gene Name 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
Synonyms 5-HT4; 5-HT4R
Species Homo sapiens
Ensembl Gene ENSG00000164270
Encoded Proteins
IDBP-52567
5-hydroxytryptamine (serotonin) receptor 4
IDBP-52569
5-hydroxytryptamine (serotonin) receptor 4
IDBP-52571
5-hydroxytryptamine (serotonin) receptor 4
IDBP-482480
5-hydroxytryptamine (serotonin) receptor 4
IDBP-485177
5-hydroxytryptamine (serotonin) receptor 4
IDBP-474176
5-hydroxytryptamine (serotonin) receptor 4
IDBP-601536
5-hydroxytryptamine (serotonin) receptor 4
IDBP-477454
5-hydroxytryptamine (serotonin) receptor 4
IDBP-479253
5-hydroxytryptamine (serotonin) receptor 4
IDBP-479747
5-hydroxytryptamine (serotonin) receptor 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:148451032-148677235
Strand Reverse strand
Band q32
Transcripts
ENST00000362016 ENSP00000355037
ENST00000360693 ENSP00000353915
ENST00000377888 ENSP00000367120
ENST00000521530 ENSP00000428320
ENST00000522588 ENSP00000430874
ENST00000521735 ENSP00000430979
ENST00000517929 ENSP00000435904
ENST00000520514 ENSP00000427913
ENST00000524063 ENSP00000430451
ENST00000521124
ENST00000519495
ENST00000520086 ENSP00000429634
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004993 serotonin receptor activity
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007210 serotonin receptor signaling pathway
GO:0007268 synaptic transmission
GO:0008284 positive regulation of cell proliferation
GO:0032098 regulation of appetite
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026322
View Gene Order
ENSBTAG00000010837
Not yet available
Pathways
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_17064
Serotonin receptors pathway
REACT_16983
Amine ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E5RHV8
UniProt Splice Variant
Entrez Gene 3360
UniGene Hs.483773
RefSeq NM_000870 NM_001040169 NM_001040172 NM_001040173 NM_001286410 NM_199453
HUGO HGNC:5299
OMIM 602164
CCDS CCDS34270 CCDS34271 CCDS34272 CCDS34273 CCDS4291 CCDS75353
HPRD
IMGT
EMBL AC008627 AC011390 AC091971 AC114939
GenPept
RNA Seq Atlas 3360

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca