InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF4E

Summary

InnateDB Protein

IDBP-477492.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF4E

Protein Name

eukaryotic translation initiation factor 4E

Synonyms

AUTS19; CBP; EIF4E1; EIF4EL1; EIF4F;

Species

Homo sapiens

Ensembl Protein

ENSP00000425561

InnateDB Gene

IDBG-30970 (EIF4E)

Protein Structure

UniProt Annotation

Function

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. {ECO:0000269PubMed:16271312, ECO:0000269PubMed:22578813}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000269PubMed:20616046}. Cytoplasm {ECO:0000250}.

Disease Associations

Autism 19 (AUTS19) [MIM:615091]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. {ECO:0000269PubMed:19556253}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. A heterozygous single-nucleotide insertion has been found in families affected by autism. The variant results in increased promoter activity and is involved in disease pathogenesis through EIF4E deregulation (PubMed:19556253). {ECO:0000269PubMed:19556253}.Note=A chromosomal aberration involving EIF4E has been found in a patient with classic autism. Translocation t(45)(q23q31.3). The breakpoint on chromosome 4 is located 56 kb downstream of EIF4E (PubMed:19556253). {ECO:0000269PubMed:19556253}.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	96 [view]
Protein-Protein	91 [view]
Protein-DNA	2 [view]
Protein-RNA	2 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000339	RNA cap binding
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0005515	protein binding
GO:0031370	eukaryotic initiation factor 4G binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006406	mRNA export from nucleus
GO:0006412	translation
GO:0006413	translational initiation
GO:0006417	regulation of translation
GO:0008286	insulin receptor signaling pathway
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019221	cytokine-mediated signaling pathway
GO:0030324	lung development
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045931	positive regulation of mitotic cell cycle

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005845	mRNA cap binding complex
GO:0010494	cytoplasmic stress granule
GO:0016281	eukaryotic translation initiation factor 4F complex
GO:0016442	RISC complex
GO:0033391	chromatoid body
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome