Version 5.4
Homo sapiens Protein: INTS8
Summary
InnateDB Protein IDBP-477629.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INTS8
Protein Name integrator complex subunit 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000430338
InnateDB Gene IDBG-29133 (INTS8)
Protein Structure
UniProt Annotation
Function Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016180 snRNA processing
Cellular Component
GO:0032039 integrator complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q75QN2
PhosphoSite PhosphoSite-Q75QN2
TrEMBL E5RJL5
UniProt Splice Variant
Entrez Gene 55656
UniGene Hs.727669
RefSeq NP_060334
HUGO HGNC:26048
OMIM 611351
CCDS CCDS34925
HPRD 08626
IMGT
EMBL AB161944 AK000537 AK001403 AK091278 AP003692 BC050536 BC064915 BC136754 BK005731 BX538203 CH471060
GenPept AAH50536 AAH64915 AAI36755 BAA91238 BAA91671 BAD10863 BAG52322 CAD98067 DAA05731 EAW91726

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca