Version 5.4
Homo sapiens Gene: INTS8
Summary
InnateDB Gene IDBG-29133.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INTS8
Gene Name integrator complex subunit 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164941
Encoded Proteins
IDBP-29135
integrator complex subunit 8
IDBP-481622
integrator complex subunit 8
IDBP-481218
integrator complex subunit 8
IDBP-474674
integrator complex subunit 8
IDBP-481699
integrator complex subunit 8
IDBP-484748
integrator complex subunit 8
IDBP-479501
integrator complex subunit 8
IDBP-477629
integrator complex subunit 8
IDBP-484586
integrator complex subunit 8
IDBP-479365
integrator complex subunit 8
IDBP-476908
integrator complex subunit 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:94813311-94881746
Strand Forward strand
Band q22.1
Transcripts
ENST00000343161 ENSP00000343274
ENST00000522171 ENSP00000429340
ENST00000523808 ENSP00000430033
ENST00000521860 ENSP00000430049
ENST00000519457 ENSP00000428260
ENST00000519053 ENSP00000429056
ENST00000524333 ENSP00000427840
ENST00000523731 ENSP00000430338
ENST00000523321
ENST00000523206 ENSP00000429452
ENST00000520526 ENSP00000430180
ENST00000520845
ENST00000520315 ENSP00000430722
ENST00000517918
ENST00000520853
ENST00000519736
ENST00000521155
ENST00000522261
ENST00000523352
ENST00000523998
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016180 snRNA processing
Cellular Component
GO:0032039 integrator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000040738
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000004902
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL E5RIN8 E5RJL5
UniProt Splice Variant
Entrez Gene 55656
UniGene Hs.727669
RefSeq NM_017864 XM_006716603
HUGO HGNC:26048
OMIM 611351
CCDS CCDS34925
HPRD 08626
IMGT
EMBL AP003692
GenPept
RNA Seq Atlas 55656

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca