InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CFTR

Summary

InnateDB Protein

IDBP-477685.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CFTR

Protein Name

cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)

Synonyms

ABC35; ABCC7; CF; CFTR/MRP; dJ760C5.1; MRP7; TNR-CFTR;

Species

Homo sapiens

Ensembl Protein

ENSP00000419254

InnateDB Gene

IDBG-37713 (CFTR)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 316 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	316 [view]
Protein-Protein	303 [view]
Protein-DNA	11 [view]
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006810	transport
GO:0045087	innate immune response (InnateDB)
GO:0055085	transmembrane transport

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001140 ABC transporter, transmembrane domain
IPR009147 Cystic fibrosis transmembrane conductance regulator
IPR011527 ABC transporter type 1, transmembrane domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00664
PF13748

PRINTS

PR01851

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite