InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EDNRA

Summary

InnateDB Protein

IDBP-477690.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EDNRA

Protein Name

endothelin receptor type A

Synonyms

ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR;

Species

Homo sapiens

Ensembl Protein

ENSP00000425354

InnateDB Gene

IDBG-40278 (EDNRA)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004930	G-protein coupled receptor activity
GO:0004962	endothelin receptor activity
GO:0005515	protein binding

Biological Process

GO:0006939	smooth muscle contraction
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007202	activation of phospholipase C activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007585	respiratory gaseous exchange
GO:0008152	metabolic process
GO:0008217	regulation of blood pressure
GO:0008283	cell proliferation
GO:0014824	artery smooth muscle contraction
GO:0015758	glucose transport
GO:0042310	vasoconstriction
GO:0048484	enteric nervous system development

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000499 Endothelin receptor family
IPR002175 Endothelin receptor A
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019427 7TM GPCR, serpentine receptor class w (Srw)

PFAM

PF00001
PF10324

PRINTS

PR00237
PR00366
PR00570

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P25101