InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNKS

Summary

InnateDB Protein

IDBP-478017.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNKS

Protein Name

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

Synonyms

ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1; TINF1; TNKS1;

Species

Homo sapiens

Ensembl Protein

ENSP00000429890

InnateDB Gene

IDBG-6906 (TNKS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003950	NAD+ ADP-ribosyltransferase activity
GO:0005515	protein binding

Biological Process

GO:0008152	metabolic process
GO:0016055	Wnt signaling pathway
GO:0032212	positive regulation of telomere maintenance via telomerase
GO:0051225	spindle assembly

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR001660 Sterile alpha motif domain
IPR002110 Ankyrin repeat
IPR011510 Sterile alpha motif, type 2
IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
IPR013761 Sterile alpha motif/pointed domain
IPR020683 Ankyrin repeat-containing domain
IPR021129 Sterile alpha motif, type 1

PFAM