InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TNKS

Summary

InnateDB Gene

IDBG-6906.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNKS

Gene Name

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

Synonyms

ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1; TINF1; TNKS1

Species

Homo sapiens

Ensembl Gene

ENSG00000173273

Encoded Proteins

IDBP-6910

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

IDBP-480405

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

IDBP-483929

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

IDBP-478017

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

IDBP-476776

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

IDBP-481441

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:9555914-9782346

Strand

Forward strand

Band

p23.1

Transcripts

ENST00000310430	ENSP00000311579
ENST00000520408	ENSP00000428299
ENST00000522110	ENSP00000430920
ENST00000517652
ENST00000518281	ENSP00000429890
ENST00000518027
ENST00000521039
ENST00000519392
ENST00000517989
ENST00000519930
ENST00000518635	ENSP00000431098
ENST00000519191
ENST00000517770	ENSP00000428185

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003950	NAD+ ADP-ribosyltransferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006471	protein ADP-ribosylation
GO:0007052	mitotic spindle organization
GO:0007067	mitotic nuclear division
GO:0008152	metabolic process
GO:0015031	protein transport
GO:0016055	Wnt signaling pathway
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0032210	regulation of telomere maintenance via telomerase
GO:0032212	positive regulation of telomere maintenance via telomerase
GO:0043392	negative regulation of DNA binding
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051028	mRNA transport
GO:0051225	spindle assembly
GO:0070198	protein localization to chromosome, telomeric region
GO:0070212	protein poly-ADP-ribosylation
GO:0070213	protein auto-ADP-ribosylation
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0000242	pericentriolar material
GO:0000775	chromosome, centromeric region
GO:0000781	chromosome, telomeric region
GO:0000784	nuclear chromosome, telomeric region
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0031965	nuclear membrane