Homo sapiens Gene: TNKS
Summary
InnateDB Gene IDBG-6906.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNKS
Gene Name tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Synonyms ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1; TINF1; TNKS1;
Species Homo sapiens
Ensembl Gene ENSG00000173273
Encoded Proteins
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 8:9555914-9782346
Strand Forward strand
Band p23.1
Transcripts
ENST00000310430 ENSP00000311579
ENST00000520408 ENSP00000428299
ENST00000522110 ENSP00000430920
ENST00000517652
ENST00000518281 ENSP00000429890
ENST00000518027
ENST00000521039
ENST00000519392
ENST00000517989
ENST00000519930
ENST00000518635 ENSP00000431098
ENST00000519191
ENST00000517770 ENSP00000428185
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 38 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006471 protein ADP-ribosylation
GO:0007052 mitotic spindle organization
GO:0007067 mitotic nuclear division
GO:0008152 metabolic process
GO:0015031 protein transport
GO:0016055 Wnt signaling pathway
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0032210 regulation of telomere maintenance via telomerase
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0043392 negative regulation of DNA binding
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051028 mRNA transport
GO:0051225 spindle assembly
GO:0070198 protein localization to chromosome, telomeric region
GO:0070212 protein poly-ADP-ribosylation
GO:0070213 protein auto-ADP-ribosylation
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0000242 pericentriolar material
GO:0000775 chromosome, centromeric region
GO:0000781 chromosome, telomeric region
GO:0000784 nuclear chromosome, telomeric region
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Signal Transduction pathway
TCF dependent signaling in response to WNT pathway
degradation of AXIN pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
Telomeres telomerase cellular aging and immortality [Biocarta view]
PID NCI
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.370267 Hs.610331 Hs.614364 Hs.711310
RefSeq NM_003747
HUGO
OMIM
CCDS CCDS5974
HPRD 04490
IMGT
EMBL
GenPept
RNA Seq Atlas